Blood Levels and and Distribution of Bacampicillin inNZW Talampicillin Rabbits
نویسندگان
چکیده
Parameters for blood concentrations of thc peroral antibiotics talampicil in and bacampicillin, in NZW rabbirs were deteTrnined using a two compartment model. On the basis of thesc pharmacokinetic parameters, a three compartment model was prepared for the concentrations of thcse drugs in the tongue, gingiva, submandibular gland, parotid gland, cervical 17mphnode and mandibular bone. Simulation curyes based on the parameters of tissue concentrations revealed visual conformit! to the measured values.
منابع مشابه
Bioavailability of bacampicillin and talampicillin, two oral prodrugs of ampicillin.
A 200-mg amount of bacampicillin showed a significantly higher relative extent of bioavailability than did a 250-mg amount of talampicillin, possibly due to their different stability in the digestive juices.
متن کاملBiol. Pharm. Bull. 30(7) 1344—1349 (2007)
amino b-lactam antibiotic. As with other ampicillin prodrugs such as pivampicillin and talampicillin, bacampicillin was developed almost 30 years ago under the hypothesis that the addition of a lipophilic moiety to the hydrophilic ampicillin molecule would improve intestinal absorption of the parent drug. It has been reported that ampicillin exhibits 33—54% bioavailability after oral administra...
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